Principal stratification analysis to determine health benefit of indoor air pollution reduction in a randomized environmental intervention in COPD: Results from the CLEAN AIR study.

ABSTRACT:

Background

Indoor air quality represents a modifiable exposure to Chronic Obstructive Pulmonary Disease (COPD) health. In a randomized controlled trial (CLEAN AIR study), air cleaner assignment had causal effect in improving COPD outcomes. It is unclear, however, what is the treatment effect among those for whom intervention reduced air pollution and whether it was reduction in fine particulate matter (PM_2.5) or nitrogen dioxide (NO₂) that contributed to such improvement. Because pollution is a posttreatment variable, treatment effect cannot be assessed while controlling for pollution using intention-to-treat (ITT) analysis.

Objective

Using principal stratification method, we assess indoor pollutants as the intermediate variable, and determine the causa

SUBMITTER: Woo H 

PROVIDER: S-EPMC9975085 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature