Integrated molecular and clinical analysis of BRAF-mutant glioma in adults.

ABSTRACT: BRAF mutations are a significant driver of disease in pediatric low-grade glioma, but the implications of BRAF alterations on the clinical course and treatment response in adult glioma remain unclear. Here, we characterize a multi-institutional cohort of more than 300 patients (>200 adults) with BRAF-mutated glioma using clinical, pathological/molecular, and outcome data. We observed that adult and pediatric BRAF-mutant gliomas harbor distinct clinical and molecular features, with a higher prevalence of BRAF^V600E (Class I) and BRAF fusions in pediatric tumors. BRAF^V600E alterations were associated with improved survival in adults with glioma overall, though not in glioblastoma. Other genomic alterations observed within functional classes were consistent with the putat

SUBMITTER: Schreck KC 

PROVIDER: S-EPMC9975216 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature