Enhanced effect of X-rays in the presence of a static magnetic field within a 3D pancreatic cancer model.

ABSTRACT:

Objective

To evaluate the impact of static magnetic field (SMF) presence on the radiation response of pancreatic cancer cells in polyurethane-based highly macro-porous scaffolds in hypoxic (1% O₂) and normoxic (21% O₂) conditions, towards understanding MR-guided radiotherapy, shedding light on the potential interaction phenomenon between SMF and radiation in a three-dimensional (3D) microenvironment.

Methods

Pancreatic cancer cells (PANC-1, ASPC-1) were seeded into fibronectin-coated highly porous polyethene scaffolds for biomimicry and cultured for 4 weeks in in vitro normoxia (21% O₂) followed by a 2-day exposure to either in vitro hypoxia (1% O₂) or maintenance in in vitro normoxia (21% O₂). The s

SUBMITTER: Wishart G 

PROVIDER: S-EPMC9975369 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature