Tri-modality therapy in advanced esophageal carcinoma: long-term results and insights from a developing world, institutional cohort.

ABSTRACT:

Objective

To evaluate treatment outcomes in patients from a low-middle income country (LMIC) with esophageal carcinoma who underwent esophagectomy after neoadjuvant chemoradiation (NACRT/S).

Methods

Between 2010 and 2020, 254 patients (median follow-up: 53 months) met our inclusion criteria. Out-of-field nodal regions were determined by reviewing individual radiotherapy plans. Cox regression modelling was performed to analyze overall survival (OS) and recurrence-free survival (RFS), while pathological complete response (pCR) prediction utilized Poisson regression.

Results

The median OS was 71.4 months (interquartile range: 19.6-∞), RFS did not reach the median and pCR rate was 46%. On multivariable Cox regression, BMI [0.93 (0.89-0.98); 0.94 (0.89-0.99)] and absence o

SUBMITTER: Chufal KS 

PROVIDER: S-EPMC9975378 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature