A pilot study exploring the association of bronchial bacterial microbiota and recurrent wheezing in infants with atopy.

ABSTRACT:

Background

Differences in bronchial microbiota composition have been found to be associated with asthma; however, it is still unclear whether these findings can be applied to recurrent wheezing in infants especially with aeroallergen sensitization.

Objectives

To determine the pathogenesis of atopic wheezing in infants and to identify diagnostic biomarkers, we analyzed the bronchial bacterial microbiota of infants with recurrent wheezing and with or without atopic diseases using a systems biology approach.

Methods

Bacterial communities in bronchoalveolar lavage samples from 15 atopic wheezing infants, 15 non-atopic wheezing infants, and 18 foreign body aspiration control infants were characterized using 16S rRNA gene sequencing. The bacterial composition and community-

SUBMITTER: Tang W 

PROVIDER: S-EPMC9975506 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature