Subtyping based on immune cell fractions reveal heterogeneity of cardiac fibrosis in end-stage heart failure.

ABSTRACT:

Background

A central issue hindering the development of effective anti-fibrosis drugs for heart failure is the unclear interrelationship between fibrosis and the immune cells. This study aims at providing precise subtyping of heart failure based on immune cell fractions, elaborating their differences in fibrotic mechanisms, and proposing a biomarker panel for evaluating intrinsic features of patients' physiological statuses through subtype classification, thereby promoting the precision medicine for cardiac fibrosis.

Methods

We inferred immune cell type abundance of the ventricular samples by a computational method (CIBERSORTx) based on ventricular tissue samples from 103 patients with heart failure, and applied K-means clustering to divide patients into two subtypes based o

SUBMITTER: Zou S 

PROVIDER: S-EPMC9975711 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature