Comparison of Sequential Intravesical Gemcitabine and Docetaxel vs Bacillus Calmette-Guerin for the Treatment of Patients With High-Risk Non-Muscle-Invasive Bladder Cancer.

ABSTRACT:

Importance

Due to the ongoing bacillus Calmette-Guérin (BCG) shortage, sequential intravesical gemcitabine and docetaxel has been increasingly used as first-line therapy for high-risk non-muscle-invasive bladder cancer (NMIBC). However, data directly comparing these 2 therapies are lacking.

Objective

To compare the outcomes of patients with high-risk NMIBC treated with gemcitabine and docetaxel vs BCG.

Design, setting, and participants

This retrospective cohort study was conducted from January 1, 2011, to December 31, 2021. The median (IQR) duration of follow-up was 23 (12-33) months for patients receiving gemcitabine and docetaxel and 49 (27-79) months for patients receiving BCG. All patients were treated at the University of Iowa tertiary care center. A total of 312

SUBMITTER: McElree IM 

PROVIDER: S-EPMC9975907 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature