Acute and Postacute COVID-19 Outcomes Among Immunologically Naive Adults During Delta vs Omicron Waves.

ABSTRACT:

Importance

The US arrival of the Omicron variant led to a rapid increase in SARS-CoV-2 infections. While numerous studies report characteristics of Omicron infections among vaccinated individuals or persons with previous infection, comprehensive data describing infections among adults who are immunologically naive are lacking.

Objectives

To examine COVID-19 acute and postacute clinical outcomes among a well-characterized cohort of unvaccinated and previously uninfected adults who contracted SARS-CoV-2 during the Omicron (BA.1/BA.2) surge, and to compare outcomes with infections that occurred during the Delta wave.

Design, setting, and participants

This prospective multisite cohort study included community-dwelling adults undergoing high-resolution symptom and virologi

SUBMITTER: Doll MK 

PROVIDER: S-EPMC9975921 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature