Ontology highlight
ABSTRACT:
SUBMITTER: Chiang IKN
PROVIDER: S-EPMC9975944 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Chiang Ivy K N IKN Graus Matthew S MS Kirschnick Nils N Davidson Tara T Luu Winnie W Harwood Richard R Jiang Keyi K Li Bitong B Wong Yew Yan YY Moustaqil Mehdi M Lesieur Emmanuelle E Skoczylas Renae R Kouskoff Valerie V Kazenwadel Jan J Arriola-Martinez Luis L Sierecki Emma E Gambin Yann Y Alitalo Kari K Kiefer Friedmann F Harvey Natasha L NL Francois Mathias M
The EMBO journal 20230130 5
Despite a growing catalog of secreted factors critical for lymphatic network assembly, little is known about the mechanisms that modulate the expression level of these molecular cues in blood vascular endothelial cells (BECs). Here, we show that a BEC-specific transcription factor, SOX7, plays a crucial role in a non-cell-autonomous manner by modulating the transcription of angiocrine signals to pattern lymphatic vessels. While SOX7 is not expressed in lymphatic endothelial cells (LECs), the con ...[more]