A neurostructural biomarker of dissociative amnesia: a hippocampal study in dissociative identity disorder.

ABSTRACT:

Background

Little is known about the neural correlates of dissociative amnesia, a transdiagnostic symptom mostly present in the dissociative disorders and core characteristic of dissociative identity disorder (DID). Given the vital role of the hippocampus in memory, a prime candidate for investigation is whether total and/or subfield hippocampal volume can serve as biological markers of dissociative amnesia.

Methods

A total of 75 women, 32 with DID and 43 matched healthy controls (HC), underwent structural magnetic resonance imaging (MRI). Using Freesurfer (version 6.0), volumes were extracted for bilateral global hippocampus, cornu ammonis (CA) 1-4, the granule cell molecular layer of the dentate gyrus (GC-ML-DG), fimbria, hippocampal-amygdaloid transition area (HATA), para

SUBMITTER: Dimitrova LI 

PROVIDER: S-EPMC9975991 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature