Childhood trauma is associated with reduced frontal gray matter volume: a large transdiagnostic structural MRI study.

ABSTRACT:

Background

Childhood trauma increases risk for psychopathology and cognitive impairment. Prior research mainly focused on the hippocampus and amygdala in single diagnostic categories. However, other brain regions may be impacted by trauma as well, and effects may be independent of diagnosis. This cross-sectional study investigated cortical and subcortical gray matter volume in relation to childhood trauma severity.

Methods

We included 554 participants: 250 bipolar-I patients, 84 schizophrenia-spectrum patients and 220 healthy individuals without a psychiatric history. Participants filled in the Childhood Trauma Questionnaire. Anatomical T1 MRI scans were acquired at 3T, regional brain morphology was assessed using Freesurfer.

Results

In the total sample, trauma-relate

SUBMITTER: Begemann MJH 

PROVIDER: S-EPMC9975993 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature