SARS-CoV-2 RNA Detected in Vitreous Samples Obtained at Autopsy.

ABSTRACT:

Purpose

This work aims to examine the vitreous of autopsy patients with COVID-19 for the presence of SARS-CoV-2 RNA.

Methods

Four deceased patients with COVID-19 had an autopsy at Massachusetts General Hospital. Two control specimens were obtained from patients undergoing retinal detachment repair with negative preoperative polymerase chain reaction (PCR) testing for SARS-CoV-2 RNA. Vitreous specimens were obtained from autopsy patients with COVID-19 after povidone was placed on the ocular surface to decrease the risk of contamination of the vitreous specimen. SARS-CoV-2 RNA for gene N (nucleocapsid) was tested using reverse transcription-PCR.

Results

SARS-CoV-2 RNA was detected in the vitreous of 2 of 4 autopsy patients who died from complications of COVID-19.

Con

SUBMITTER: Tieger M 

PROVIDER: S-EPMC9976118 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature