Identification of key genes and pathways associated with gender difference in osteonecrosis of the femoral head based on bioinformatics analysis.

ABSTRACT:

Objective

To identify different key genes and pathways between males and females by studying differentially expressed genes (DEGs).

Methods

The gene expression data of GSE123568 were downloaded from GEO database, including osteonecrosis of the femoral head (ONFH) samples from 3 females and 7 males, and DEGs between different gender were identified with R software. Protein-protein interaction (PPI) network was constructed to further analyze the interactions between overlapping DEGs, and finally, GO, KEGG and gene set enrichment analysis (GSEA) were conducted for enrichment analysis.

Results

131 DEGs were identified between ONFH females and ONFH males, including 76 up-regulated genes and 55 down-regulated genes. And 10 hub genes were identified in PPI network, including

SUBMITTER: Yan Z 

PROVIDER: S-EPMC9976184 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature