Direct Activation of the C(sp³)-NH₂ Bond of Primary Aliphatic Alkylamines by a High-Valent Co^III,IV₂(μ-O)₂ Diamond Core Complex.

ABSTRACT: Aliphatic alkylamines are abundant feedstock and versatile building blocks for many organic transformations. While remarkable progress has been made to construct C-N bonds on aliphatic and aromatic carbon centers, the activation and functionalization of C(sp³)-NH₂ bonds in primary alkylamines remain a challenging process. In the present work, we discovered an unprecedented method to directly activate the C(sp³)-NH₂ bond of primary alkylamines by a high-valent dinuclear Co^III,IV₂(μ-O)₂ diamond core complex. This reaction results in the installation of other functional groups such as halides and alkenes onto the α-carbon center concomitant with the 2-e^- oxidation of the nitrogen atom on the amino group to

SUBMITTER: Li Y 

PROVIDER: S-EPMC9976198 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature