Activating and repressing gene expression between chromosomes during stochastic fate specification.

ABSTRACT: DNA elements act across long genomic distances to regulate gene expression. During transvection in Drosophila, DNA elements on one allele of a gene act between chromosomes to regulate expression of the other allele. Little is known about the biological roles and developmental regulation of transvection. Here, we study the stochastic expression of spineless (ss) in photoreceptors in the fly eye to understand transvection. We determine a biological role for transvection in regulating expression of naturally occurring ss alleles. We identify DNA elements required for activating and repressing transvection. Different enhancers participate in transvection at different times during development to promote gene expression and specify cell fates. Bringing a silencer element on a heterologous chromo

SUBMITTER: Urban EA 

PROVIDER: S-EPMC9976292 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature