Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status.

ABSTRACT:

Introduction

Despite the association of vitamin D deficiency with incident dementia, the role of supplementation is unclear. We prospectively explored associations between vitamin D supplementation and incident dementia in 12,388 dementia-free persons from the National Alzheimer's Coordinating Center.

Methods

Baseline exposure to vitamin D was considered D+; no exposure prior to dementia onset was considered D-. Kaplan-Meier curves compared dementia-free survival between groups. Cox models assessed dementia incidence rates across groups, adjusted for age, sex, education, race, cognitive diagnosis, depression, and apolipoprotein E (APOE) ε4. Sensitivity analyses examined incidence rates for each vitamin D formulation. Potential interactions between exposure and model c

SUBMITTER: Ghahremani M 

PROVIDER: S-EPMC9976297 | biostudies-literature | 2023 Jan-Mar

REPOSITORIES: biostudies-literature