FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1α/VEGF signaling pathway.

ABSTRACT:

Background

Preeclampsia (PE) is a complication of pregnancy that causes long-term adverse outcomes for the mother and fetus and may even lead to death. Oxidative stress caused by the imbalance of oxidants and antioxidants in the placenta has been considered as one of the key mechanisms of preeclampsia (together with inflammation, etc.), in which the placental mitochondria play an important role. The expression of hypoxia-inducible factor-1 (HIF-1α) and vascular endothelial growth factor (VEGF) is known to be increased in patients with PE. Mitochondrial ferritin (FtMt) is known to protect the mitochondria from oxidative stress, although its specific role in PE remains unclear.

Methods

We used qRT-PCR and western blotting to detect the expression levels of FtMt, HIF-1α, and VE

SUBMITTER: Xu X 

PROVIDER: S-EPMC9976428 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature