Robust 3D modeling reveals spatiosyntenic properties of animal genomes.

ABSTRACT: Animal genomes are organized into chromosomes that are remarkably conserved in their gene content, forming distinct evolutionary units (synteny). Using versatile chromosomal modeling, we infer three-dimensional topology of genomes from representative clades spanning the earliest animal diversification. We apply a partitioning approach using interaction spheres to compensate for varying quality of topological data. Using comparative genomics approaches, we test whether syntenic signal at gene pair, local, and whole chromosomal scale is reflected in the reconstructed spatial organization. We identify evolutionarily conserved three-dimensional networks at all syntenic scales revealing novel evolutionarily maintained interactors associated with known conserved local gene linkages (such as hox)

SUBMITTER: Clarence T 

PROVIDER: S-EPMC9976460 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature