Impact of obesity and white adipose tissue inflammation on the omental microenvironment in endometrial cancer.

ABSTRACT:

Background

A complex relationship between adipose tissue and malignancy, involving an inflammatory response, has been reported. The goal of this work was to assess the prevalence of white adipose tissue (WAT) inflammation in patients with endometrial cancer (EC), and the association with circulating inflammation markers. Furthermore, the aim was to characterize the pathways activated in and the cell type composition of adipose tissue in patients with EC.

Methods

Adipose tissue and blood samples were prospectively collected from 101 patients with EC at initial surgery. WAT inflammation was determined based on adipocytes surrounded by macrophages forming crown-like structures. Circulating levels of metabolic syndrome-associated and inflammatory markers were quantified. RNA-seq

SUBMITTER: Moukarzel LA 

PROVIDER: S-EPMC9976596 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature