Benchmarking functional connectivity by the structure and geometry of the human brain.

ABSTRACT: The brain's structural connectivity supports the propagation of electrical impulses, manifesting as patterns of coactivation, termed functional connectivity. Functional connectivity emerges from the underlying sparse structural connections, particularly through polysynaptic communication. As a result, functional connections between brain regions without direct structural links are numerous, but their organization is not completely understood. Here we investigate the organization of functional connections without direct structural links. We develop a simple, data-driven method to benchmark functional connections with respect to their underlying structural and geometric embedding. We then use this method to reweigh and reexpress functional connectivity. We find evidence of unexpectedly stron

SUBMITTER: Liu ZQ 

PROVIDER: S-EPMC9976650 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature