Oligonucleotide usage in coronavirus genomes mimics that in exon regions in host genomes.

ABSTRACT:

Background

Viruses use various host factors for their growth, and efficient growth requires efficient use of these factors. Our previous study revealed that the occurrence frequency of oligonucleotides in the influenza virus genome is distinctly different among derived hosts, and the frequency tends to adapt to the host cells in which they grow. We aimed to study the adaptation mechanisms of a zoonotic virus to host cells.

Methods

Herein, we compared the frequency of oligonucleotides in the genome of alpha- and betacoronavirus with those in the genomes of humans and bats, which are typical hosts of the viruses.

Results

By comparing the oligonucleotide frequency in coronaviruses and their host genomes, we found a statistically tested positive correlation between the fr

SUBMITTER: Iwasaki Y 

PROVIDER: S-EPMC9976658 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature