Childhood exposure to per- and polyfluoroalkyl substances and neurodevelopment in the CHARGE case-control study.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFAS) are shown to have neurotoxic effects on animals, but epidemiological evidence for associations between childhood PFAS exposure and neurodevelopment is inconclusive. We examined if childhood PFAS concentrations are associated with a diagnosis of autism spectrum disorder (ASD), developmental delay (DD), and other early concerns (OEC) in development.

Methods

We included 551 children 2-5 years old from the CHildhood Autism Risks from Genetics and Environment (CHARGE) case-control study. Children were clinically diagnosed and classified as having ASD, DD, OEC, and typical development (TD). Fourteen PFAS were quantified in child serum samples collected when diagnostic assessments were performed. We used multinomial logistic reg

SUBMITTER: Oh J 

PROVIDER: S-EPMC9976729 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature