Identification of a serum and urine extracellular vesicle signature predicting renal outcome after kidney transplant.

ABSTRACT:

Background

A long-standing effort is dedicated towards the identification of biomarkers allowing the prediction of graft outcome after kidney transplant. Extracellular vesicles (EVs) circulating in body fluids represent an attractive candidate, as their cargo mirrors the originating cell and its pathophysiological status. The aim of the study was to investigate EV surface antigens as potential predictors of renal outcome after kidney transplant.

Methods

We characterized 37 surface antigens by flow cytometry, in serum and urine EVs from 58 patients who were evaluated before, and at 10-14 days, 3 months and 1 year after transplant, for a total of 426 analyzed samples. The outcome was defined according to estimated glomerular filtration rate (eGFR) at 1 year.

Results

End

SUBMITTER: Burrello J 

PROVIDER: S-EPMC9976747 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature