Abnormal resting-state functional connectivity underlies cognitive and clinical symptoms in patients with schizophrenia.

ABSTRACT:

Introduction

The cognitive and psychotic symptoms in patients with schizophrenia (SZ) are thought to result from disrupted brain network connectivity.

Methods

We capitalize on the high spatiotemporal resolution of magnetoencephalography imaging (MEG) to record spontaneous neuronal activity in resting state networks in 21 SZ compared with 21 healthy controls (HC).

Results

We found that SZ showed significant global disrupted functional connectivity in delta-theta (2-8 Hz), alpha (8-12 Hz), and beta (12-30 Hz) frequencies, compared to HC. Disrupted global connectivity in alpha frequencies with bilateral frontal cortices was associated with more severe clinical psychopathology (i.e., positive psychotic symptoms). Specifically, aberrant connectivity in beta frequencies bet

SUBMITTER: Jia Y 

PROVIDER: S-EPMC9976937 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature