Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration.

ABSTRACT: Blood-based biomarkers for amyloid beta and phosphorylated tau show good diagnostic accuracies and agreements with their corresponding CSF and neuroimaging biomarkers in the amyloid/tau/neurodegeneration [A/T/(N)] framework for Alzheimer's disease. However, the blood-based neurodegeneration marker neurofilament light is not specific to Alzheimer's disease while total-tau shows lack of correlation with CSF total-tau. Recent studies suggest that blood total-tau originates principally from peripheral, non-brain sources. We sought to address this challenge by generating an anti-tau antibody that selectively binds brain-derived tau and avoids the peripherally expressed 'big tau' isoform. We applied this antibody to develop an ultrasensitive blood-based assay for brain-derived tau, and validated

SUBMITTER: Gonzalez-Ortiz F 

PROVIDER: S-EPMC9976981 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature