Contribution of labor related gene subtype classification on heterogeneity of polycystic ovary syndrome.

ABSTRACT:

Objective

As one of the most common endocrine disorders in women of reproductive age, polycystic ovary syndrome (PCOS) is highly heterogeneous with varied clinical features and diverse gestational complications among individuals. The patients with PCOS have 2-fold higher risk of preterm labor which is associated with substantial infant morbidity and mortality and great socioeconomic cost. The study was designated to identify molecular subtypes and the related hub genes to facilitate the susceptibility assessment of preterm labor in women with PCOS.

Methods

Four mRNA datasets (GSE84958, GSE5090, GSE43264 and GSE98421) were obtained from Gene Expression Omnibus database. Twenty-eight candidate genes related to preterm labor or labor were yielded from the researches and our unp

SUBMITTER: Zhou J 

PROVIDER: S-EPMC9977056 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature