Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization.

ABSTRACT:

Objectives

To examine associations between PsA and psoriasis vs lifestyle factors and comorbidities by triangulating observational and genetic evidence.

Methods

We analysed cross-sectional data from the UK Biobank (1836 PsA, 8995 psoriasis, 36 000 controls) to describe the association between psoriatic disease and lifestyle factors (including BMI and smoking) and 15 comorbidities [including diabetes and coronary artery disease (CAD)] using logistic models adjusted for age, sex and lifestyle factors. We applied bidirectional Mendelian randomization (MR) to genome-wide association data (3609 PsA and 7804 psoriasis cases, up to 1.2 million individuals for lifestyle factors and 757 601 for comorbidities) to examine causal direction, using the inverse-variance weighted method.

SUBMITTER: Zhao SS 

PROVIDER: S-EPMC9977114 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature