Robust analysis of prokaryotic pangenome gene gain and loss rates with Panstripe.

ABSTRACT: Horizontal gene transfer (HGT) plays a critical role in the evolution and diversification of many microbial species. The resulting dynamics of gene gain and loss can have important implications for the development of antibiotic resistance and the design of vaccine and drug interventions. Methods for the analysis of gene presence/absence patterns typically do not account for errors introduced in the automated annotation and clustering of gene sequences. In particular, methods adapted from ecological studies, including the pangenome gene accumulation curve, can be misleading as they may reflect the underlying diversity in the temporal sampling of genomes rather than a difference in the dynamics of HGT. Here, we introduce Panstripe, a method based on generalized linear regression that is robu

SUBMITTER: Tonkin-Hill G 

PROVIDER: S-EPMC9977150 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature