Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish.

ABSTRACT: Although germline cells are considered to be functionally "immortal," both the germline and supporting somatic cells in the gonad within an organism experience aging. With increased age at parenthood, the age-related decline in reproductive success has become an important biological issue for an aging population. However, molecular mechanisms underlying reproductive aging across sexes in vertebrates remain poorly understood. To decipher molecular drivers of vertebrate gonadal aging across sexes, we perform longitudinal characterization of the gonadal transcriptome throughout the lifespan in the naturally short-lived African turquoise killifish (Nothobranchius furzeri). By combining mRNA-seq and small RNA-seq from 26 individuals, we characterize the aging gonads of young-adult, middl

SUBMITTER: Teefy BB 

PROVIDER: S-EPMC9977155 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature