Relationships of Cerebral Perfusion With Gait Speed Across Systolic Blood Pressure Levels and Age: A Cohort Study.

ABSTRACT:

Background

This study aimed to examine if the association of cerebral perfusion with gait speed differs across systolic blood pressure (SBP) and age.

Methods

Cerebral perfusion was measured via arterial spin labeled (ASL)-MRI among community-dwelling adults aged 31-94 years in the population-based Mayo Clinic Study of Aging. Usual gait speed was assessed over 5.6 meters on an electronic mat. Sex- and body mass index (BMI)-adjusted linear regression models estimated cross-sectional gait speed associations with ASL and modifying effects of age and SBP using 3-way and 2-way interaction terms between continuous age, SBP, and ASL. Results report estimated differences in gait speed per standard deviation (SD) lower ASL for exemplar SBPs and ages.

Results

Among 479 participa

SUBMITTER: Windham BG 

PROVIDER: S-EPMC9977228 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature