Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons.

ABSTRACT: Neuromodulation serves as a cornerstone for brain sciences and clinical applications. Recent reports suggest that mid-infrared stimulation (MIRS) causes non-thermal modulation of brain functions. Current understanding of its mechanism hampers the routine application of MIRS. Here, we examine how MIRS influences the sensorimotor transformation in awaking-behaving pigeons, from neuronal signals to behavior. We applied MIRS and electrical stimulation (ES) to the pretectal nucleus lentiformis mesencephali (nLM), an essential retinorecipient structure in the pretectum, and examined their influences on the optokinetic nystagmus, a visually guided eye movement. We found MIRS altered eye movements by modulating a specific gain depending on the strength of visual inputs, in a manner different than

SUBMITTER: Xiao T 

PROVIDER: S-EPMC9977280 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature