Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain.

ABSTRACT:

Background

Higher-order cognition is hypothesized to be implemented via distributed cortical networks that are linked via long-range connections. However, it is unknown how computational advantages of long-range connections reflect cortical microstructure and microcircuitry.

Methods

We investigated this question by (i) profiling long-range cortical connectivity using resting-state functional magnetic resonance imaging (MRI) and cortico-cortical geodesic distance mapping, (ii) assessing how long-range connections reflect local brain microarchitecture, and (iii) examining the microarchitectural similarity of regions connected through long-range connections.

Results

Analysis of 2 independent datasets indicated that sensory/motor areas had more clustered short-range conne

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9977370 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature