Palladium- and Brønsted acid-catalyzed enantio-, site- and E/Z-selective addition of alkylidenecyclopropanes with imines† † Electronic supplementary information (ESI) available: Experimental procedures, characterization data, and copies of NMR spectra. CCDC 2203909. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d2sc05674g

ABSTRACT: Transition-metal catalyzed functionalization of ACPs has been widely investigated in cycloaddition and 1,3-difunctionalization reactions. However, the transition metal catalyzed nucleophilic reactions of ACPs have rarely been reported. In this article, an enantio-, site- and E/Z-selective addition of ACPs with imines for the synthesis of dienyl substituted amines has been developed via palladium- and Brønsted acid co-catalysis. A range of synthetically valuable dienyl substituted amines were effectively prepared with good to excellent yields and excellent enantio- and E/Z-selectivities. An enantio-, site- and E/Z-selective addition of ACPs with imines for the synthesis of dienyl substituted amines has been developed via palladium- and Brønsted acid co-catalysis.

SUBMITTER: Liu X 

PROVIDER: S-EPMC9977444 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature