A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny.

ABSTRACT: Newborns are at high risk of developing neonatal sepsis, particularly if born prematurely. This has been linked to divergent requirements the immune system has to fulfill during intrauterine compared with extrauterine life. By transcriptomic analysis of fetal and adult neutrophils, we shed new light on the molecular mechanisms of neutrophil maturation and functional adaption during fetal ontogeny. We identified an accumulation of differentially regulated genes within the noncanonical NF-κB signaling pathway accompanied by constitutive nuclear localization of RelB and increased surface expression of TNF receptor type II in fetal neutrophils, as well as elevated levels of lymphotoxin α in fetal serum. Furthermore, we found strong upregulation of the negative inflammatory regulator A20 (Tnfai

SUBMITTER: Rohwedder I 

PROVIDER: S-EPMC9977499 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature