Prenatal perfluoroalkyl substances exposure and maternal sex steroid hormones across pregnancy.

ABSTRACT:

Background

Poly- and perfluoroalkyl substances (PFAS) are ubiquitous and persistent environmental contaminants that may act as endocrine disruptors in utero, but the specific endocrine pathways are unknown.

Objective

We examined associations between maternal serum PFAS and sex steroid hormones at three time points during pregnancy.

Methods

Pregnant women participating in the Understanding Pregnancy Signals and Infant Development (UPSIDE) study contributed biospecimens, questionnaire, and medical record data in each trimester (n = 285). PFAS (including perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA)) were analyzed in second-trimester serum samples

SUBMITTER: Rivera-Nunez Z 

PROVIDER: S-EPMC9977559 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature