Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment^1,2. Less than half of all patients respond to the primary treatment for PDAC, chemotherapy^3,4, and genetic alterations alone cannot explain this⁵. Diet is an environmental factor that can influence the response to therapies, but its role in PDAC is unclear. Here, using shotgun metagenomic sequencing and metabolomic screening, we show that the microbiota-derived tryptophan metabolite indole-3-acetic acid (3-IAA) is enriched in patients who respond to treatment. Faecal microbiota transplantation, short-term dietary manipulation of tryptophan and oral 3-IAA administration increase

SUBMITTER: Tintelnot J 

PROVIDER: S-EPMC9977685 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature