The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer.

ABSTRACT:

Background

Neuroendocrine prostate cancer (NEPC) is a multi-resistant variant of prostate cancer (PCa) that has become a major challenge in clinics. Understanding the neuroendocrine differentiation (NED) process at the molecular level is therefore critical to define therapeutic strategies that can prevent multi-drug resistance.

Methods

Using RNA expression profiling and immunohistochemistry, we have identified and characterised a gene expression signature associated with the emergence of NED in a large PCa cohort, including 169 hormone-naïve PCa (HNPC) and 48 castration-resistance PCa (CRPC) patients. In vitro and preclinical in vivo NED models were used to explore the cellular mechanism and to characterise the effects of castration on PCa progression.

Results

We show

SUBMITTER: Blanc C 

PROVIDER: S-EPMC9977768 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature