Clinical utility of liquid biopsy and integrative genomic profiling in early-stage and oligometastatic cancer patients treated with radiotherapy.

ABSTRACT:

Background

Liquid biopsy and Integrative Genomic Profiling (IGP) are yet to be implemented into routine Radiation Oncology. Here we assess the utility of germline, tumour and circulating cell-free DNA-based genomic analyses for the clinical management of early-stage and oligometastatic cancer patients treated by precision radiotherapy.

Methods

We performed germline, tissue- and liquid biopsy NGS panels on 50 early-stage/oligometastatic cancer patients undergoing radiotherapy. We also monitored ctDNA variants in serial liquid biopsies collected during radiotherapy and follow-up and evaluated the clinical utility of such comprehensive approach.

Results

The integration of different genomic studies revealed that only 1/3 of the liquid biopsy variants are of tumour origin.

SUBMITTER: Cifuentes GA 

PROVIDER: S-EPMC9977775 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature