Regional citrate anticoagulation for replacement therapy in patients with liver failure: A systematic review and meta-analysis.

ABSTRACT:

Background

Citrate refers to an anticoagulant agent commonly used in extracorporeal organ support. Its application is limited in patients with liver failure (LF) due to the increased risk of citrate accumulation induced by liver metabolic dysfunction. This systematic review aims to assess the efficacy and safety of regional citrate anticoagulation in extracorporeal circulation for patients with liver failure.

Methods

PubMed, Web of Science, Embase, and Cochrane Library were searched. Studies regarding extracorporeal organ support therapy for LF were included to assess the efficacy and safety of regional citrate anticoagulation. Methodological quality of included studies were assessed using the Methodological Index for Non-randomized Studies (MINORS). Meta-analysis was perfor

SUBMITTER: Peng B 

PROVIDER: S-EPMC9977825 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature