Genome-wide hydroxymethylation profiles in liver of female Nile tilapia with distinct growth performance.

ABSTRACT: The mechanisms underlying the fast genome evolution that occurs during animal domestication are poorly understood. Here, we present a genome-wide epigenetic dataset that quantifies DNA hydroxymethylation at single nucleotide resolution among full-sib Nile tilapia (Oreochromis niloticus) with distinct growth performance. In total, we obtained 355 million, 75 bp reads from 5 large- and 5 small-sized fish on an Illumina NextSeq500 platform. We identified several growth-related genes to be differentially hydroxymethylated, especially within gene bodies and promoters. Previously, we proposed that DNA hydroxymethylation greatly affects the earliest responses to adaptation and potentially drives genome evolution through its targeted enrichment and elevated nucleotide transversion rates. This data

SUBMITTER: Konstantinidis I 

PROVIDER: S-EPMC9977925 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature