Association of Proton Pump Inhibitor/Histamine-2 Blocker Use and Ocular Toxoplasmosis: Findings from a Large US National Database.

ABSTRACT:

Objective

To test the hypothesis that the use of proton pump inhibitors (PPIs) is associated with an increased risk of being diagnosed with toxoplasmic retinochoroiditis.

Design

Retrospective, matched case-control study using data from 2000 to 2020.

Participants

Patients with ocular toxoplasmosis and controls were matched 5:1 for age, sex, and race, with the eligibility date ± 3 months from the index date of exposed match. Patients aged < 18 years with congenital toxoplasmosis, having < 2 years in the insurance plan before the index date, and without ≥ 1 visit to an eyecare provider before the index date were excluded from the study.

Methods

Patients with ocular toxoplasmosis were identified using the International Classification of Diseases, Ninth Revision and

SUBMITTER: Conrady CD 

PROVIDER: S-EPMC9978037 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature