Organocatalytic asymmetric synthesis of P-stereogenic molecules.

ABSTRACT: P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodologies for the synthesis of P-stereogenic molecules. Different catalytic systems are emphasized for each strategy class (desymmetrization, kinetic resolution, and dynamic kinetic resolution) with examples cited to illustrate the potential applications of the accessed P-stereogenic organophosphorus compounds.

SUBMITTER: Liu J 

PROVIDER: S-EPMC9978094 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature