Aberrant degree centrality of functional brain networks in subclinical depression and major depressive disorder.

ABSTRACT:

Background

As one of the most common diseases, major depressive disorder (MDD) has a significant adverse impact on the li of patients. As a mild form of depression, subclinical depression (SD) serves as an indicator of progression to MDD. This study analyzed the degree centrality (DC) for MDD, SD, and healthy control (HC) groups and identified the brain regions with DC alterations.

Methods

The experimental data were composed of resting-state functional magnetic resonance imaging (rs-fMRI) from 40 HCs, 40 MDD subjects, and 34 SD subjects. After conducting a one-way analysis of variance, two-sample t-tests were used for further analysis to explore the brain regions with changed DC. Receiver operating characteristic (ROC) curve analysis of single index and composite inde

SUBMITTER: Yang L 

PROVIDER: S-EPMC9978101 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature