Exploration of novel biomarkers in Alzheimer's disease based on four diagnostic models.

ABSTRACT:

Background

Despite tremendous progress in diagnosis and prediction of Alzheimer's disease (AD), the absence of treatments implies the need for further research. In this study, we screened AD biomarkers by comparing expression profiles of AD and control tissue samples and used various models to identify potential biomarkers. We further explored immune cells associated with these biomarkers that are involved in the brain microenvironment.

Methods

By differential expression analysis, we identified differentially expressed genes (DEGs) of four datasets (GSE125583, GSE118553, GSE5281, GSE122063), and common expression direction of genes of four datasets were considered as intersecting DEGs, which were used to perform enrichment analysis. We then screened the intersecting pathways

SUBMITTER: Zou C 

PROVIDER: S-EPMC9978156 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature