Cerebral white matter lesions and regional blood flow are associated with reduced cognitive function in early-stage cognitive impairment.

ABSTRACT:

Background

Differences in the extent of cerebral white matter lesions (WML) and regional cerebral blood flow (rCBF) in early-stage cognitive impairment (ESCI) contribute to the prognosis of cognitive decline; however, it is unclear precisely how WML and rCBF affect cognitive decline in ESCI.

Objective

We examined the association between WML, rCBF, and cognitive impairment in the ESCI, using path analysis to clarify how these variables affect each other.

Methods

Eighty-three patients who consulted our memory clinic regarding memory loss were included in this study based on the Clinical Dementia Rating. Participants underwent the Mini-Mental State Examination (MMSE), brain magnetic resonance imaging (MRI) for voxel-based morphometry analysis, and brain perfusion single-

SUBMITTER: Kuroda T 

PROVIDER: S-EPMC9978183 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature