Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells.

ABSTRACT: Monoclonal antibodies (mAb) have gained enormous therapeutic application during the last decade as highly efficient and flexible tools for the treatment of various diseases. Despite this success, there remain opportunities to drive down the manufacturing costs of antibody-based therapies through cost efficiency measures. To reduce production costs, novel process intensification methods based on state-of-the-art fed-batch and perfusion have been implemented during the last few years. Building on process intensification, we demonstrate the feasibility and benefits of a novel, innovative hybrid process that combines the robustness of a fed-batch operation with the benefits of a complete media exchange enabled through a fluidized bed centrifuge (FBC). In an initial small-scale FBC-mimic screen

SUBMITTER: Reger LN 

PROVIDER: S-EPMC9978186 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature