Association between psychotropic medication and sleep microstructure: evidence from large population studies.

ABSTRACT:

Study objectives

To assess the association between psychotropic medications and sleep microstructure in large community-based cohorts of older people.

Methods

We analyzed overnight polysomnograms of 381 women from the Study of Osteoporotic Fractures (SOF) and 2,657 men from the Osteoporotic Fractures in Men Sleep Study (MrOS), who either used no psychotropic medication (n = 2,819), only benzodiazepines (n = 112), or only selective serotonin reuptake inhibitors (SSRI) (n = 107). Sleep microstructure (cyclic alternating pattern, CAP) was compared between the no medication group and psychotropic medication groups using the Mann-Whitney U test. Significant differences were investigated using multivariable linear regression adjusted for confounders.

Results

CAP rate

SUBMITTER: Hartmann S 

PROVIDER: S-EPMC9978436 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature