Plasma concentration of orally administered amoxicillin and clindamycin in patients receiving haemodialysis.

ABSTRACT:

Objectives

In the randomized controlled trial PANTHEM, the prophylactic effect of oral amoxicillin or clindamycin is investigated in patients receiving chronic haemodialysis (HD). However, data on plasma concentrations of these antibiotics during HD are sparse. This study aims to determine if the plasma concentration of amoxicillin and clindamycin is sufficient during HD after oral administration of amoxicillin and clindamycin at three different time intervals prior to the HD procedure.

Methods

Adult patients receiving chronic HD were investigated twice with an interval of at least 7 days starting with either a tablet of 500/125 mg amoxicillin/clavulanic acid or a tablet of 600 mg clindamycin. Patients were randomized to take the antibiotics either 30, 60 or 120 min prior to

SUBMITTER: Solli CN 

PROVIDER: S-EPMC9978593 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature