Vibration of effect in more than 16 000 pooled analyses of individual participant data from 12 randomised controlled trials comparing canagliflozin and placebo for type 2 diabetes mellitus: multiverse analysis.

ABSTRACT:

Objective

To evaluate the impact of conducting all possible pooled analyses across different combinations of randomised controlled trials and endpoints.

Design

Multiverse analysis, consisting of numerous pooled analyses of individual participant data.

Setting

Individual patient data from 12 randomised controlled trials comparing canagliflozin treatment with placebo, shared on the Yale University Open Data Access project (https://yoda.yale.edu/) platform, up to 16 April 2021.

Participants

15 094 people with type 2 diabetes mellitus.

Main outcome measures

Pooled analyses estimated changes in serum glycated haemoglobin (HbA1c), major adverse cardiovascular events, and serious adverse events at weeks 12, 18, 26, and 52. The distribution of effect estimates w

SUBMITTER: Gouraud H 

PROVIDER: S-EPMC9978683 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature