Appraisal of the causal effect of plasma caffeine on adiposity, type 2 diabetes, and cardiovascular disease: two sample mendelian randomisation study.

ABSTRACT:

Objective

To investigate the potential causal effects of long term plasma caffeine concentrations on adiposity, type 2 diabetes, and major cardiovascular diseases.

Design

Two sample mendelian randomisation study.

Setting

Genome-wide association study summary data for associations of two single nucleotide polymorphisms associated with plasma caffeine at the genome-wide significance threshold (rs2472297 near the CYP1A2 gene and rs4410790 near the AHR gene) and their association with the outcomes.

Participants

Primarily individuals of European ancestry participating in cohorts contributing to genome-wide association study consortia.

Main outcome measures

Outcomes studied were body mass index, whole body fat mass, whole body fat-free mass, type

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC9978685 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature